Imaging Analysis of Primary Laryngeal Amyloidosis (a Report of 9 Cases) <?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

刘庆余  陈健宇

张  嵘  叶瑞心  梁碧玲

中山大学附属孙逸仙纪念医院放射科

广州市沿江西路107号  510120

Qingyu Liu, Jianyu Chen, Rong Zhang et, al

Department of Radiology，Sun Yat-sen Memorial Hospital，Sun Yat-sen University

Guangzhou，  Guangdong Province  510120    P.R.China

ABSTRAC

Purpose: To improve the diagnosis and understanding of primary laryngeal amyloidosis by analyzing its imaging findings. 　　

Materials and Methods: 9 cases of primary laryngeal amyloidosis were confirmed pathologically, including 6 males and 3 females. 4 cases of CT exams and 5 cases of MR exams were performed  respectively.

Results: 5 of 9 cases demonstrated localized nodular or mass-like appearances; the laryngeal structures show diffuse thickening in 3 cases, causing airway stenosis or deformity, no obvious nodule or mass were present; 1 case demonstrated combined imaging findings, showing diffusely thickened laryngeal structures with localized nodular appearance. CT value of the lesions was 39.9-69Hu, and calcification was identified in one case. the signal intensity  is similar to muscle tissue on T1WI, and hypointense  to muscle on T2WI.

Conclusion: Imaging exam is very important in detecting the contour, type and extent of primary laryngeal amyloidosis£¬ but it still needs biopsy to establish the diagnosis.

Key words: Larynx; Imaging study; Amyloidosis

原发性喉淀粉样变或称淀粉样瘤是一种少见病，是一种局部蛋白质代谢异常疾病。国内外有关淀粉样变影像学表现的文献报道较少[1]。本文收集了9例经手术证实的原发性喉淀粉样变，现报道如下，旨在提高对喉淀粉样变的认识。

一般资料

本组9例中男性６例，女性3例，年龄36－64（平均48.3岁）。9例在临床上均表现为声嘶，病程最短为２个月，最长11年，平均为23.4个月，有２例伴有喉异物感，３例伴呼吸不畅，１例刺激性干咳，１例反复咽痛、咽干。所有病例均在支撑喉镜下行肿物切除证实。

5例ＭＲ检查采用荷兰Philips公司Gyroscan 0.5Ｔ超导型磁共振成像设备，应用自旋回波（SE）序列，均采用表面线圈，T1WI：TR/TE为479-561/15-25ms，NSA（信号采集次数）为4，T2WI：TR/TE为1800-2226/80-90ms，NSA为2－8，层厚为4-6ｍｍ，间距为0.4-0.6ｍｍ，扫描矩阵为205×256，采集横断位及冠状或矢状图像，3例行Gd-DTPA增强扫描，剂量为0.1mmol/kg。４例ＣＴ检查采用Siemens ART型全身CT扫描机，层厚为3-5ｍｍ，层间距为3-5ｍｍ。