Advances in Microwave ablation Therapy of Liver Tumor

Shao Qiu-Jie

Department of Ultrasound , General Hospital of PLA,Beijing 100853

Abstract In the past two decades, various local ablation techniques of liver tumor under imaging guidance were widely used, and these techniques preserve more liver tissue and keep lower mortality than liver tumor excise while achieved the similar clinical efficacy. Among which, microwave coagulation therapy became an important one because of complete tumor ablation and good clinical efficacy. We reviewed this technique from its mechanism, indication, machine development, clinical efficacy and complications.

Key words: microwave ablation, liver tumor

自从上个世纪80年代末微波消融治疗（MCT）肝恶性肿瘤应用以来，这项技术已经应用20年，并在肝癌治疗中取得了令人满意的临床疗效，成为肝癌综合治疗中的一项重要技术。目前应用该技术的地区主要在日本和中国。本文从微波消融治疗肝癌原理、适应证、仪器发展、临床疗效、和并发症几方面回顾该技术的发展。

一 、微波消融治疗肝癌原理

目前临床用于治疗肝癌的微波发生器产生的微波频率为2450MHz，波长为12cm^[1]。MCT时将微波能量通过微波辐射电极导入组织,在电极周围形成辐射场，生物组织中的带电离子和极性分子在微波交变电场中产生离子振动及极化旋转运动并摩擦碰撞，引起生物组织温度迅速升高，达到组织消融坏死的温度，从而灭活肿瘤。