fMRI evaluation of NGF gene therapy on neural functional recoveryin the region of perihematoma after intracerebral hemorrhage

刘怀军

(河北医科大学第二医院放射科,河北石家庄　050000)<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

LIU Huaijun

Department of Radiology, the Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China

Abstract

Objective：To study the applied value of using fMRI to evaluate the therapeutic effect of NGF gene on neural functional re2covery in the region of perihematoma after experimental intracerebral hemorrhage (ICH).

Methods：Twenty2four healthy dogs were dividedinto three groups randomly：NGF group ( n＝ 12), ICH group ( n＝8) and control group ( n＝4).　The examinations of Purdy score, MRscanning and TEM were carried out at 1, 3, 10, 28 day after ICH.

Results：Compared with ICH group, the volume of hematoma and ede2ma in NGF group had no significant difference ( P > 0.05), whereas ADC and rCBF in NGF group had significant difference at 1 - 3 day( P< 0.05). At 10 - 28 day, the volume of hematoma and edema, ADC and rCBF in NGF group were obviously better than that in ICHgroup ( P < 0.05). The dynamic changes of MR were correlated with the changes of clinic neural function and pathological result.

Conclur： sion fMRI was an objective and effective method to evaluate quantitatively and qualitatively the results of gene therapy.

Key words：Intracerebral hemorrhage； Functional magnetic resonance imaging； Gene therapy； NGF