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The effect of endostatin gene in combination with radiotherapy on rats with implanted tumor

李勇  金宁  杨海山

LI Yong，JIN Ning，YANG Hai－shan，et al．

China－Japan Union Hospital of Ji lin University，Chang chun l30033，China

Abstract

　　Objective：To study the effect Of combinating Of the radiotherapy with endostatin gene therapy on the rats with implanted tumor．

　　Methods：lmmediate Walker－256 cancerous ascetic iniection method was used to make a rat tumor－bearing model，then the tumor was treated with saline，endostatin gene，irradiation or endostatin gene plus irradiation．The tumor growth rate and weight were observed，Western blot and RT－PCR were adopted to check the expressions of endostatin mRNA and protein．