Assessment VX2 tumor after radiofrequency ablation by conrast-enhanced ultrasonography<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

裴小青　李安华　梁惠宏　周建华　蔡木炎　张耀军　陈芳

Pei Xiaoqing Li Anhua Liang Huihong Zhou Jianhua Cai Muyan Zhang Yaojun Chen Fang

State Key Laboratory of Oncology in Southern China，Guangzhou，Guangdong，510060，China

Department of Ultrasonics，Cancer Center，Sun Yant-sen University，Guangzhou，Guangdong，510060，China

Abstract

　　Objective：To explore the reliability of conrast enhangced ultrasonography(CEUS) in assessing the response of heptic tumors after radiofrequency ablation(RFA) compared with histopathology.

　　Methods：VX2 tumors （1×1×1mm³）were implanted into 8 New Zealand rabbits，and 8 tumors were harvested RFA was applied to each tumor with for 140.1±25.5 seconds to ensure incomplete tumor ablation. CEUS was performed 4 days after RFA following with histopathologic examination. The largest diameters of all leasions after RFA in CEUS were compared with that of fresh specimens. CEUS-histopathologic correlation was analyzed in almost the same plane of CEUS imaging and pathologic specimens

　　Results：Residual tumors were found in 7 of 8 rabbits，benign periablational enhancement in 4 of 8 lesions，the same as histopathologic analysis. The difference between the largest diameters after RFA in CEUS and that of fresh specimens was without statistical significance. CEUS correlated well with histopathology considering the areas of percentage of the necrosis（r＝0.986）

　　Conclusion：CEUS can accurately discriminate the coagulation necrosis from residual tumors after RFA in a few days，and detect benign periablational enhancement. It is an effective methods to adequately assess the adequate treatment of a given tumor. It will play an important role in clinic

　　Key words：contrast enhanced ultrasonography  radiofrequency ablation VX2 tumor