Evaluation of Efficacy and Influence Factors of Interventional Therapy by Hepatic Artery for Liver Metastases<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

李槐^*　闫东^*　刘德忠^*　曾辉英^*　周纯武^*　魏文强^△　张毅成^#　马晓东^#　杨立新^#　万胜^#
*中国医学科学院影像诊断科，北京 100021
△中国医学科学院肿瘤研究所流行病学室，北京 100021
#进修生

　　　　　　　　　　　　　　ABSTRACT
　　Objective：To evaluate the prognostic factors and efficacy of interventional therapy by hepatic artery for liver metastases.
　　Methods：167 patients with unresectable liver metastases were treated by interventional therapy through hepatic artery in 434 times, the infusion was accepted in 31 patients, embolization was combinationed in 136. Antitumor agents were selected according to the origin lesion. Embolization was accomplished with lipiodol ultra-fluid (LUF) or / and gelatin sponge. Cox regression was used in proportional hazard analysis.
　　Results：Median survival period (MS) of 167 patients was 13.0 months. An overall response rate (CR+PR) of the cases was 52.7%. The 0.5-, 1.0-, 2.0-, 3.0-, 5.0-year survival rate was 80.8%, 55%, 21.7%, 12% and 6.8%, respectively. There were no severe side effects or complications. Cox regression was showed: MS of patients with blood-supply-poor and multiple lesions were shorter than other patients (P=0.000 and 0.001, respectively). It also displayed the patients with tumor thrombus in portal vein and the primary lesions survived shorter than others (P=0.027 and 0.049,respectively).
　　Conclusion：The interventional therapy by hepatic artery is a better method for liver metastases. The blood-supply-rich, single lesion, without tumor thrombus in portal vein and the primary lesions have been resected were the most important influence factors in hepatic arterial chemotherapy and embolization of the liver metastases.
　　Key words：Liver metastases;Interventional therapy;Hepatic artery;Cox regression